Experimental anergy: III Suppressive macrophage factor

Late pregnancy suppresses relapses in experimental autoimmune encephalomyelitis: evidence for a suppressive pregnancy-related serum factor.

Women with multiple sclerosis have significantly diminished disease activity during pregnancy. The purpose of our study was to identify the underlying mechanism for the diminished disease activity. We found that during the period of late pregnancy there is protection against paralysis, during both the induction and effector phases of relapsing experimental autoimmune encephalomyelitis, a mouse ...

Macrophage Migration Inhibitory Factor

Macrophage Colony-Stimulating Factor

Macrophage Plasticity in Experimental Atherosclerosis

As in human disease, macrophages (MØ) are central players in the development and progression of experimental atherosclerosis. In this study we have evaluated the phenotype of MØ associated with progression of atherosclerosis in the apolipoprotein E (ApoE) knockout (KO) mouse model.We found that bone marrow-derived MØ submitted to M1 and M2 polarization specifically expressed arginase (Arg) II a...

Macrophage migration in experimental atherosclerosis.

With the object of testing the importance of macrophage transport of lipid in the production of atheromas, a radioisotope was employed in labeling reticuloendothelial cells. Rabbits were injected with this isotope, and lipernia induced by cholesterol feeding. SuLsequently the animals were sacrificed and the distribution of the label determined. High concentrations of the label were found in Kup...